Penis Pathology Study Guide

Penis pathology refers to lesions or abnormalities of the penis.

Penis pathology includes:

Hypospadias

Hypospadias is an opening of the urethra on the penis’s inferior surface.

Hypospadias results as a failure of the urethral folds to close properly.

Hypospadias. Different types of hyposadias Centers for Disease Control and Prevention - Not altered. CC0
Hypospadias. Example of penis with hypospadias Buddy I Con -Not altered. Public Domain
Hypospadias. Penis with hypospadias (1) and two fistulae (2). Not altered. CC BY-SA 3.0
Hypospadias. Nesbit's preputial tissue transfer for hypospadias. The forked flap repair for hypospadias. Chadha A, Singh A - Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India (2012). Not altered. CC.
Hypospadias on physical examination. (A-D) Illustrate varying severity of hypospadias from mild to severe. Black arrows, urethral meatus located proximally; white arrows, the abnormal foreskin.Do endocrine disruptors cause hypospadias? Botta S, Cunha GR, Baskin LS - Translational andrology and urology (2014). Not Altered. CC.

Epispadias is the opening of the urethra on the superior surface of the penis.

Epispadias is the result of abnormal positioning of the genital tubercle.

Epispadias is linked to bladder exstrophy.

Surgical intervention may benefit patients with epispadias.

Epispadias. Watercolour drawing showing the condition of epispadias. From a boy aged two years. Medical Photographic Library Keywords: Mark, Leonard Portal Not altered. CC BY 4.0

Condyloma acuminata is a benign warty growth on genital skin.

Human papilloma virus (HPV) infections that are known to cause condyloma acuminata include:

Histology of condyloma acuminata is characterized by koilocytic change.

Condyloma. A woman afflicted with genital warts, also called condylomata acuminata, around the anus. These warts are caused by human papillomavirus (HPV). SOA-AIDS Amsterdam. not altered. CC BY-SA 3.0
Pigmented Seborrehic Keratosis of the Vulva. This was a single SK amid multiple condylomata acuminata removed at the same time. Ed Uthman. Not altered. CC BY 2.0

Lymphogranuloma venereum is necrotizing granulomatous inflammation of the inguinal lymphatics and lymph nodes.

Lymphogranuloma venereum is a sexually transmitted disease caused by Chlamydia trachomatis (serotypes Ll-L3).

Lymphogranuloma venereum lesions that heal subsequently result in fibrosis.

Perianal involvement of lymphogranuloma venereum can lead to rectal stricture.

Lymphogranuloma Venereum. Lymphogranuloma venereum: is caused by the invasive serovars L1, L2, or L3 of Chlamydia trachomatis. This young adult experienced the acute onset of tender, enlarged lymph nodes in both groins. Herbert L. Fred, MD and Hendrik A. van Dijk. Not altered. CC BY 2.0

Squamous cell carcinoma (SCC) may occur on the penis.

Risk factors for squamous cell carcinoma (SCC) include:

Squamous Cell Carcinoma. Squamous cell carcinoma, well differentiated, left upper paraspinal back marked for biopsy with adjacent actinic keratosis. Dermanonymous. Not altered. CC BY-SA 4.0
A residual “grenz zone” of uninvolved tissue characterized by a dense lymphocytic infiltrate was evident. Neoplastic cells exhibited marked pleomorphism with anaplastic and multinucleated giant cells. The mesenchymal proliferation was lined by an atypical squamous epithelium (H and E, ×40). A bone fide atypical fibroxanthoma of penis. Cuomo R, Addesso M, Altieri R, D'Antonio A - Urology annals (2014). Not Altered. CC.
: Histological findings showed triple cancer (magnification of background image: ×40, insert: ×400). (a) Hematoxylin-eosin (HE) staining of the small cell carcinoma of the bladder. (b) Immunohistochemical staining for CD56 demonstrated CD56-positive cells. (c) HE staining of the prostatic urethral tumor demonstrated papillary growth and malignancy. (d) HE staining of the penis showed cancer pearls and single-cell keratinocytes that are characteristic of squamous cell carcinoma.The probability of involvement of human papillomavirus in the carcinogenesis of bladder small cell carcinoma, prostatic ductal adenocarcinoma, and penile squamous cell carcinoma: a case report. Ogawa S, Yasui T, Taguchi K, Umemoto Y, Kojima Y, Kohri K - BMC research notes (2014). Not Altered. CC.