Very high magnification micrograph of confluent epidermal necrosis. Skin biopsy. H&E stain. Confluent epidermal necrosis is seen in the context of erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). SJS and TEN are generally considered to be on a spectrum and usually due to medications. EM is histomorphologically indistinguishable from SJS/TEN. It is usually due to an infection. Histomorphologic features: A basket weave-type stratum corneum (indicative of the acuity). Epidermal necrosis. Separation of the epidermis and dermis. Minimal inflammation. Nephron. Not altered. CC BY-SA 3.0
Skin The skin serves as a defense against fluid loss and environmental irritants. Skin is made up of a dermis and an epidermis. The epidermis is composed of keratinocytes and has five layers: Basale Spinosum Granulosum Lucidum Corneum The regenerative…
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