What is Phyllodes Tumor?

Phyllodes Tumor
The primary phyllodes tumor in the left breast had leaf-like architecture of epithelial cells and high-grade malignant stromal overgrowth (H&E, ×4 (a), magnificent). The tumor partially containing 1.0 × 0.9 cm SCC in the primary site: SCC partially have contact with epithelial cells of phyllodes tumor (H&E, ×4 (b), magnificent). AE1/3 was positive on SCC and negative on the phyllodes tumor (×10 (c), magnificent). H&E, hematoxylin and eosin; SCC, squamous cell carcinoma.Malignant phyllodes tumor metastasized to the right ventricle: a case report. Yoshidaya F, Hayashi N, Takahashi K, Suzuki K, Akiyama F, Ishiyama M, Takahashi Y, Yoshida A, Yagata H, Nakamura S, Tsunoda H, Yamauchi H - Surgical case reports (2015). Not ALtered. CC.

Phyllodes tumor is a biphasic fibroepithelial neoplasm with leaf-like epithelial (phyllodal) pattern and stromal proliferation.

What is the Pathology of Phyllodes Tumor?

The pathology of phyllodes tumor is:

-Etiology: The cause of phyllodes tumor is currently unclear.

-Genes involved: MED12 and RARA mutations.

-Pathogenesis: The sequence of events that lead to phyllodes tumor is the loss of epithelial interaction with stromal components. There is increased incidence of Phyllodes tumor in Li-Fraumeni syndrome.

-Morphology: The morphology associated with phyllodes tumor shows a palpable breast mass.

-Histology: The histology associated with phyllodes tumor shows the leaf-like epithelial pattern formed by an exaggerated intracanalicular pattern, subepithelial condensation with increased stromal cellularity adjacent to epithelium, cystic degeneration, hemorrhage, stromal hyalinization, and myxoid change.

How does Phyllodes Tumor Present?

Patients with phyllodes tumor typically are female with breast masses

How is Phyllodes Tumor Diagnosed?

Phyllodes tumor is diagnosed through the histologic diagnosis. .

How is Phyllodes Tumor Treated?

Phyllodes tumor is treated by local excision with clear margins.

What is the Prognosis of Phyllodes Tumor?

The prognosis of phyllodes tumor is fair.

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Last updated on May 27, 2022