Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. 

What is the Pathology of Osteomalacia?

The pathology of osteomalacia is:

-Etiology: The cause of osteomalacia is vitamin D deficiency. 

-Genes involved: FGF-23, PHEX mutations.

-Pathogenesis: The sequence of events that lead to osteomalacia is the coordinated process of bone remodeling. 

-Histology: The histology associated with osteomalacia shows a wide, noncalcified matrix surrounding disorganized bone trabeculae.

How does Osteomalacia Present?

Patients with osteomalacia typically affect both males and females in their adulthood. The symptoms, features, and clinical findings associated with osteomalacia include diffuse body pains, muscle weakness, and fragility of the bones. 

How is Osteomalacia Diagnosed?

Osteomalacia is diagnosed by biopsy of a long bone or iliac crest.

How is Osteomalacia Treated?

Osteomalacia is treated by administration of vitamin D3. 

What is the Prognosis of Osteomalacia?

The prognosis of osteomalacia is good.