Paget disease of the bone is a condition involving cellular remodeling and deformity of one or more bones. 

What is the Pathology of Paget Disease of the Bone?

The pathology of Paget disease of the bone is:

-Etiology: The cause of Paget disease of the bone is unknown. 

-Genes involved: SQSTM1 and RANK.

-Pathogenesis: The sequence of events that lead to Paget disease of the bone involves an increase in osteoclastic resorption of bone. 

-Histology: The histology associated with Paget disease of the bone shows primarily woven bone, a focal mosaic pattern of lamellar bone, resembling a jigsaw puzzle with prominent irregular cement lines.

How does Paget Disease of the Bone Present?

Patients with Paget disease of the bone typically affect males more than females over 55 years of age. The symptoms, features, and clinical findings associated with Paget disease of the bone include bone pain.

How is Paget Disease of the Bone Diagnosed?

Paget disease of the bone is diagnosed usually by elevated alkaline phosphatase in the blood. 

How is Paget Disease of the Bone Treated?

Paget disease of the bone is treated with bisphosphonates, calcitonin, supplements such as Vitamin D and calcium, NSAIDs, and acetaminophen for pain management.

What is the Prognosis of Paget Disease of the Bone?

The prognosis of Paget disease of the bone is progressive and slowly worsens with time, although people may remain minimally symptomatic.