What are Chondrosarcomas?

Chondrosarcomas
Hematoxylin and eosin staining of sections from our patient's pelvic tumor mass and skull metastasis. (A) Low-power photomicrograph demonstrating the low-grade chondrosarcoma (black arrows) arising in the stalk of a pre-existing osteochondroma (white arrows). (B) Focally within the stalk of the osteochondroma, the tumor had features of clear cell chondrosarcoma. (C) The skull metastasis consisted entirely of the clear cell chondrosarcoma component.Response to sunitinib in combination with proton beam radiation in a patient with chondrosarcoma: a case report. Dallas J, Imanirad I, Rajani R, Dagan R, Subbiah S, Gaa R, Dwarica WA, Ivey AM, Zlotecki RA, Malyapa R, Indelicato DJ, Scarborough MT, Reith JD, Gibbs CP, Dang LH - Journal of medical case reports (2012). Not Altered. CC.

Chondrosarcoma is a type of bone cancer that develops in cartilage cells. 

What is the Pathology of Chondrosarcomas?

The pathology of chondrosarcomas is:

-Etiology: The cause of chondrosarcomas is unknown. 

-Genes involved: IDH, CDKN2A, and COL2A1.

-Pathogenesis: The sequence of events that lead to chondrosarcomas are the chromosomal anomalies detected in some types of chondrosarcomas including 9p21, 10, 13q14, and 17p13. 

-Histology: The histology associated with chondrosarcomas shows recognizable lacunae, often containing binucleated or multinucleated chondrocytes. 

How do Chondrosarcomas Present?

Patients with chondrosarcomas typically affect middle-aged males. The symptoms, features, and clinical findings associated with chondrosarcomas include back or thigh pain, sciatica, bladder symptoms, and unilateral edema.

How are Chondrosarcomas Diagnosed?

Chondrosarcomas are diagnosed by imaging studies (X-ray, CT scan, MRI) in combination with biopsy specimens. 

How is Chondrosarcomas Treated?

Chondrosarcomas are treated by wide surgical resection. 

What is the Prognosis of Chondrosarcomas?

The prognosis of chondrosarcomas is poor. 

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Last updated on May 27, 2022