HLA associations reported with serious ADRs caused by many different drugs. This is not an exhaustive list of reported drug-HLA associations but illustrates that the pattern of drug–HLA–tissue injury interactions vary and that there is no general rule for predicting susceptibility. New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity: Pirmohamed M, Ostrov DA, Park BK - The Journal of allergy and clinical immunology (2015). Not altered. CC.