What is Basal Cell Carcinoma of the Ear?

Basal Cell Carcinoma of the Ear
High-risk basal cell carcinoma on the ear. a Large sclerosing ulcerated plaque infiltrating and eroding the ear helix. A punch biopsy confirmed the presence of infiltrating basal cell carcinoma (BCC). b Final defect after 2 Mohs surgery stages and c side-to-side clousure. d Stage I Mohs map showing positive deep and lateral margins affected and e the ear cartilage (hematoxylin and eosin staining, original magnification ×40). f Stage II showed no residual BCC. Courtesy of Dr Zilinsky and Dr Bennassar. Management of high-risk and advanced basal cell carcinoma. Puig S, Berrocal A - Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2015). Not Altered. CC.

Basal cell carcinoma of the ear is a nest of basaloid cells with peripheral palisading associated with a fibromyxoid stroma.

What is the Pathology of Basal Cell Carcinoma of the Ear?

The pathology of basal cell carcinoma of the ear is: 

-Etiology: The cause of basal cell carcinoma of the ear is typically UV radiation.

-Genes involved: TP53, PTCH1, SMO, CDKN2A, RAS.

-Pathogenesis: The sequence of events that lead to basal cell carcinoma of the ear is UV radiation induced carcinogenesis, mutations in TP53 gene, PTCH1 gene mutations, and activating mutations in SMO gene and other genes including mutations in the CDKN2A gene and RAS genes.

-Histology: The histology associated with basal cell carcinoma of the ear shows basophilic palisading groups of cells. 

How does Basal Cell Carcinoma of the Ear Present?

Patients with basal cell carcinoma of the ear typically are male present at the age range of middle aged adults with increasing incidence with age. The symptoms, features, and clinical findings associated with basal cell carcinoma of the ear include a nodular variant that usually presents as a pearly pink or flesh colored papule or nodule with arborizing and branching vessels. The borders of basal cell carcinomas are typically rolled. 

How is Basal Cell Carcinoma of the Ear Diagnosed?

Basal cell carcinoma of the ear is diagnosed by clinical features, dermatoscopy, and histological features.

How is Basal Cell Carcinoma of the Ear Treated?

Basal cell carcinoma of the ear is treated by surgery. 

What is the Prognosis of Basal Cell Carcinoma of the Ear?

The prognosis of basal cell carcinoma of the ear is fair.