What is Squamous Cell Hyperplasia of the Vulva?

Squamous Cell Hyperplasia of the Vulva
Immunohistochemistry of HMGA2 in vulva tumors. (A) HMGA2 immunostaining of case 5, an SCC (x50, magnification). (B) HMGA2 immunostaining of case 20, a vulvar MM (x50, magnification). Inset shows immunohistochemistry at a higher magnification (x200). SCC, squamous cell carcinoma; MM, malignant melanoma. HMGA2 expression pattern and TERT mutations in tumors of the vulva. Agostini A, Panagopoulos I, Andersen HK, Johannesen LE, Davidson B, Tropé CG, Heim S, Micci F - Oncology reports (2015). Not Altered. CC.

Squamous cell hyperplasia of the vulva is an abnormal growth of vulvar skin which mostly occurs before menopause.  

What is the Pathology of Vulvar Squamous Cell Hyperplasia?

The pathology of vulvar squamous cell hyperplasia is:

-Etiology: The cause of vulvar squamous cell hyperplasia is chronic irritation results due to detergents, fabric conditioners, clothes, perfumed soaps.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to vulvar squamous cell hyperplasia are: increased numbers of squamous cells causing increased thickness of the squamous epithelium, which might be diffused or form blunt papillary projections.

-Morphology: The morphology associated with vulvar squamous cell hyperplasia shows thick, enlarged swollen skin.

-Histology: The histology associated with vulvar squamous cell hyperplasia shows hyperkeratosis and acanthosis.

How does Vulvar Squamous Cell Hyperplasia Present?

Patients with vulvar squamous cell hyperplasia typically in females before age of 40 to 50 years. The symptoms, features, and clinical findings associated with vulvar squamous cell hyperplasia include itching, redness, thick and hard patches on vulva.

How is Vulvar Squamous Cell Hyperplasia Diagnosed?

Vulvar squamous cell hyperplasia is diagnosed by biopsy. 

How is Vulvar Squamous Cell Hyperplasia Treated?

Vulvar squamous cell hyperplasia is treated by steroid creams twice daily. 

What is the Prognosis of Vulvar Squamous Cell Hyperplasia?

The prognosis of vulvar squamous cell hyperplasia is good. Since it is a non-malignant condition so no mortality is associated with it.

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Last updated on May 26, 2022