What is Carcinoma of the Endometrium?

Carcinoma of the Endometrium
(A) Negative control (a breast cancer sample positive for FXYD3) where the primary FXYD3 was replaced by phosphate-buffered saline showed no staining for FXYD3 in tumor cells (arrow). (B) FXYD3-negative expression in epithelial cells of the normal endometrium. (arrow). (C) Moderate expression of FXYD3 in the epithelial cells of atypical endometrial hyperplasia (arrow). (D) Strong expression of FXYD3 in the tumor cells of the endometrial cancer (arrow). Expression and clinical significance of FXYD3 in endometrial cancer. Li Y, Zhang X, Xu S, Ge J, Liu J, Li L, Fang G, Meng Y, Zhang H, Sun X - Oncology letters (2014). Not Altered. CC.

Carcinoma of the endometrium or endometrial cancer is a type of uterine cancer that starts in the inner lining of the uterus called endometrium. 

What is the Pathology of Endometrium Carcinoma?

The pathology of endometrium carcinoma is:

-Etiology: The cause of endometrium carcinoma is DNA mutations which turns normal, healthy cells into abnormal cells. 

-Genes involved: MLH1, MSH2, MSH6, PMS2, BRCA1, BRCA2, MUTYH, CHEK2, TP53, and POLD1 EPCAM genes.  

-Pathogenesis: The sequence of events that lead to endometrium carcinoma

-Morphology: The morphology associated with endometrium carcinoma shows small tufts and papillae, greater cytological atypia.

-Histology: The histology associated with endometrium carcinoma shows aty

How does Endometrium Carcinoma Present?

Patients with endometrium carcinoma typically females with average age 60, and uncommon in women under 45 years age. The symptoms, features, and clinical findings associated with endometrium carcinoma include pain, mass in pelvic area, pain during intercourse, painful urination, and postmenopausal bleeding.

How is Endometrium Carcinoma Diagnosed?

Endometrium carcinoma is diagnosed by endometrial biopsy, hysteroscopy, dilation and curettage.

How is Endometrium Carcinoma Treated?

Endometrium carcinoma is treated by: radiation therapy, surgery to remove uterus, hormone therapy, chemotherapy, 

What is the Prognosis of Endometrium Carcinoma?

The prognosis of endometrium carcinoma is good the 5 years survival rate on average is 81% for all the stages of the endometrial cancer.  

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Last updated on May 26, 2022