What is Salmonellosis?

Salmonellosis
Model for PERP's role in the inflammatory response to Salmonella infection. Left box: Salmonella invades the intestine and secretes SipA into the extracellular space. Infection induces a series of separate, although intertwined, PERP‐mediated events. Path A: Panel 1: WT. Salmonella infection induces increased expression of PERP. We propose this is due in part to the perturbation of endosome trafficking previously observed during Salmonella infection, thus preventing PERP degradation. Panel 2: Increased PERP expression leads to an increase in cellular stores of activated caspase‐3. Path B: Panel 1. SipA acts, likely in concert with other effectors, at the apical surface to trigger the redistribution of PERP. As described above, endosomal networks have been shown to be disrupted during Salmonella infection. Panel 2. At the apical surface, PERP facilitates the organization of a protein complex that binds to SipA and to SipC. Panel 3. We propose that the protein complex functions to stabilize SipA at the apical surface such that it can be cleaved by caspase‐3 into its functional domains. PERP, a host tetraspanning membrane protein, is required for S almonella ‐ induced inflammation. Cellular Microbiology. Not Altered. CC.

Salmonella is a type of bacteria that can affect the intestinal tract.

What is the Pathology of Salmonellosis?

The pathology of salmonellosis is:

-Etiology: The cause of salmonellosis is food poisoning.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to salmonellosis is salmonella ingested in food survive passage through the gastric acid barrier and invade the mucosa of the small and large intestine and produce toxins. Invasion of epithelial cells stimulates the release of proinflammatory cytokines which induce an inflammatory reaction.

-Histology: The histology associated with salmonellosis shows enteropathy.

How does Salmonellosis Present?

Patients with Salmonellosis typically all genders at all ages. The symptoms, features, and clinical findings associated with salmonellosis include diarrhea, fever, and stomach cramps.

How is Salmonellosis Diagnosed?

Salmonellosis is diagnosed by testing a sample of stool, body tissue, or fluids.

How is Salmonellosis Treated?

Salmonellosis is treated by fluoroquinolones for adults and azithromycin for children.

What is the Prognosis of Salmonellosis?

The prognosis of salmonellosis is very good. it is a self-limiting disease in most patients. Even immunosuppressed patients can do well if the disease is diagnosed and treated promptly.

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Last updated on May 25, 2022