What is Colitis-Associated Neoplasia?

Colitis-Associated Neoplasia
Immunohistochemical findings for CCL20 and CCR6 in the rectal mucosa. CCL20 expression was observed in the nuclei of the epithelial and inflammatory cells and the lymphoid follicles. (A) Weak and (B) strong expression of CCL20 in the rectal mucosa. CCR6 expression was observed in the nuclei and cytoplasm of the epithelial, infiltrating inflammatory and endothelial cells. (C) Weak and (D) strong expression of CCR6 in the rectal mucosa (labeled streptavidin-biotin staining; magnification, ×100). Correlation of CCL20 expression in rectal mucosa with the development of ulcerative colitis-associated neoplasia. Hashimoto K, Saigusa S, Araki T, Tanaka K, Okita Y, Fujikawa H, Kawamura M, Okugawa Y, Toiyama Y, Inoue Y, Uchida K, Mohri Y, Kusunoki M - Oncology letters (2013). Not Altered. CC.

Colitis-associated neoplasia is one of the most important causes for morbidity and mortality in patients with inflammatory bowel diseases. 

What is the Pathology of Colitis-Associated Neoplasia?

The pathology of disease in lower case is:

-Etiology: The cause of colitis-associated neoplasia is inflammatory bowel disease.

-Genes involved: SMAD, WNT, β-catenin.

-Pathogenesis: The sequence of events that lead to colitis-associated neoplasia are: Multiple processes like tumor initiation and metastasis are involved in colitis-associated neoplasia. The pathogenesis of CAC is reported to be affected by multiple pathways, including TGF-β/SMAD, WNT/β-catenin, NOD/TLR, NLRP3 inflammasome, and the cell cycle as well as apoptosis.

-Histology: The histology associated with colitis-associated neoplasia shows colonic neoplasia.

How does Colitis-Associated Neoplasia Present?

Patients with colitis-associated neoplasia typically all genders at all ages. The symptoms, features, and clinical findings associated with colitis-associated neoplasia include urgent bowel movements as well as cramps.

How is Colitis-Associated Neoplasia Diagnosed?

Colitis-associated neoplasia is diagnosed by sigmoidoscope, MRI, CT scan.

How is Colitis-Associated Neoplasia Treated?

Colitis-associated neoplasia is treated by drug therapy or surgery.

What is the Prognosis of Colitis-Associated Neoplasia?

The prognosis of colitis-associated neoplasia is fair.

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Last updated on May 25, 2022