Hemophilia A is the most common hereditary cause of serious bleeding. It is an X-linked recessive disorder caused by reduced factor VIII activity.

What is the Pathology of Hemophilia A?

The pathology of hemophilia a is:

-Etiology: The cause of hemophilia a is mutations in factor VIII.

-Genes involved: F8.

-Pathogenesis: The sequence of events that lead to hemophilia a includes the deficit in factor VIII,  or by an acquired inhibitor that binds factor VIII.

-Histology: The histology associated with hemophilia a shows missing factor VIII and hemarthrosis.

How does Hemophilia A Present?

Patients with hemophilia a typically affect the male present in the age range of 26-45 years. The symptoms, features, and clinical findings associated with hemophilia include spontaneous hemorrhages in joints, muscles and with life-threatening hemorrhage, and petechiae.

How is Hemophilia A Diagnosed?

Hemophilia a is diagnosed with specific assays for factor VIII.

How is Hemophilia A Treated?

Hemophilia a is treated with factor VIII infusions.

What is the Prognosis of Hemophilia A?

The prognosis of hemophilia a is poor with 50-60% of people having a severe form of the disorder.