Fibrinolysis suppression in sepsis. Microorganisms, their products, and endogenous inflammatory mediators may lead to hypofibrinolysis by enhancing the release of plasminogen activator inhibitors (mainly PAI-1), particularly by endothelial cells. The same agents may variably influence the release of t-PA (see text for further details). Sepsis-associated disseminated intravascular coagulation and thromboembolic disease. Semeraro N, Ammollo CT, Semeraro F, Colucci M - Mediterranean journal of hematology and infectious diseases (2010). Not Altered. CC.