What is Ankylosing Spondyloarthritis?

Ankylosing Spondyloarthritis
a Representative immunohistochemical (IHC) images of peripheral synovia of AS, RA, or OA stained with antibodies against IL-32 or isotype controls. Synovitis was found in the tissues acquired from the patients with clinically active AS (36-year-old female, ankle) and RA (52-year-old female, ankle). b Representative IHC images of axial skeletons of advanced AS (57-year-old female) and OA (79-year-old female) patients who underwent laminectomy. All IHC images are shown at 200× magnification (scale bars, 100 μm), and are representative of images from three independent experiments. AS ankylosing spondylitis, IL interleukin, OA osteoarthritis RA, rheumatoid arthritis. High level of interleukin-32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation: Lee EJ, Lee EJ, Chung YH, Song DH, Hong S, Lee CK, Yoo B, Kim TH, Park YS, Kim SH, Chang EJ, Kim YG - Arthritis research & therapy (2015). Not altered. CC.

Ankylosing Spondyloarthritis is a type of arthritis that mainly affects the spine. 

What is the Pathology of Ankylosing Spondyloarthritis?

The pathology of ankylosing spondyloarthritis is:

-Etiology: The cause of ankylosing spondyloarthritis is unknown. 

-Genes involved: HLA-B27.

-Pathogenesis: The sequence of events that lead to ankylosing spondyloarthritis is HLA-B27 associated inflammation of the spinal joints. 

-Histology: The histology associated with ankylosing spondyloarthritis shows diffuse lymphocytes and plasma cells infiltrate. Lymphoid follicles may also be present. 

How does Ankylosing Spondyloarthritis Present?

Patients with ankylosing spondyloarthritis may be male or female. Symptoms typically begin before 45 years of age. The symptoms, features, and clinical findings associated with ankylosing spondyloarthritis include insidious onset of back pain in the sacroiliac joints, which progresses to involve other areas of the spine. Exercise helps ease the pain and stiffness. 

How is Ankylosing Spondyloarthritis Diagnosed?

Ankylosing spondyloarthritis is diagnosed with physical examinations, laboratory tests, and imaging studies.

How is Ankylosing Spondyloarthritis Treated?

Ankylosing spondyloarthritis is treated with physical therapy and NSAIDS.

What is the Prognosis of Ankylosing Spondyloarthritis?

The prognosis of ankylosing spondyloarthritis is fair. 

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Last updated on May 24, 2022