What are Ganglion Cysts?

Ganglion Cysts
Melanopsin-expressing retinal ganglion cells and myelin ultrastructure. a Retinal cross-sections from a healthy control individual were stained with antibody against melanopsin. The inner retina shows the ganglion cell layer with retinal ganglion cells (arrows) and one melanopsin-expressing retinal ganglion cell (asterisk). b The inner retina from a patient with LHON reveals a melanopsin-expressing retinal ganglion cell (asterisk) in the complete absence of other retinal ganglion cells. c Electron micrograph of optic nerve cross-sections from a healthy control individual showing densely packed axons with the variable axonal calibre and normal myelin thickness. d A representative illustration from a patient with LHON highlights the dramatic depletion of axons with a thin myelin coating around the surviving axons. A neurodegenerative perspective on mitochondrial optic neuropathies: Acta Neuropathologica. Not altered. CC.

Ganglion cysts are nodular lesions that most commonly develop in the wrist. 

What is the Pathology of Ganglion Cysts?

The pathology of ganglion cysts is:

-Etiology: The cause of ganglion cysts is unknown. 

-Genes involved: None. 

-Pathogenesis: The sequence of events that lead to ganglion cysts is unknown. 

-Histology: The histology associated with ganglion cysts shows cystic lesions that are lined by connective tissue. Ganglion cysts are typically composed of bland spindle-shaped cells in a background of myxoid matrix.

How does Ganglion Cysts Present?

Patients with ganglion cysts typically present with pain, and a subcutaneous nodule.

How are Ganglion Cysts Diagnosed?

Ganglion cysts are usually diagnosed utilizing physical examination, ultrasound, and needle aspiration. 

How Are Ganglion Cysts Treated?

Many ganglion cysts resolve on their own. Needle aspiration or surgery may be considered for certain patients.

What is the Prognosis of Ganglion Cysts?

The prognosis of ganglion cysts is good. 

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Last updated on May 24, 2022