What is Tenosynovial Giant Cell Tumor?

Tenosynovial Giant Cell Tumor
A 55-year-old female with right posterior calf pain was initially diagnosed with tenosynovial giant cell tumor with subsequent resection demonstrating a malignant tenosynovial giant cell tumor. Pathology of core biopsy and resection specimens is shown. (a) A core biopsy sample of the mass stained with Hematoxylin and eosin, ×400, shows epithelioid cells with round nuclei and background of lymphocytes, histiocytes, several multinucleated giant cells (thick arrows), and scattered mitoses (thin arrow). Hemosiderin is also present (arrowhead). (b) Although the majority of the resection specimen appears similar to the core biopsy, select areas of the resection stained with Hematoxylin and eosin (×400), display pleomorphic cytology with large, highly atypical cells (arrow) and atypical mitoses (arrowhead), consistent with the diagnosis of malignant diffuse-type TGCT.

Tenosynovial giant cell tumors are a group of rare, benign tumors that involve bursae, synovium, and tendon sheath.

What is the Pathology of Tenosynovial Giant Cell Tumor?

The pathology of tenosynovial giant cell tumor is:

-Etiology: The cause of tenosynovial giant cell tumor is unknown. 

-Genes involved: None. 

-Pathogenesis: The sequence of events that lead to tenosynovial giant cell tumors is unknown. 

-Histology: The histology associated with tenosynovial giant cell tumors shows mononuclear stromal cells with small round nuclei.

How does Tenosynovial Giant Cell Tumor Present?

Patients with tenosynovial giant cell tumors are males or females typically between 25 and 40 years old. The signs and symptoms of tenosynovial giant cell tumors vary depending upon the location, but tend to include swelling. 

How is Tenosynovial Giant Cell Tumor Diagnosed?

Tenosynovial giant cell tumor is diagnosed using X-ray and MRI.

How is Tenosynovial Giant Cell Tumor Treated?

Tenosynovial giant cell tumor is treated using surgical excision.

What is the Prognosis of Tenosynovial Giant Cell Tumor?

The prognosis of tenosynovial giant cell tumors is fair.

Tags:
Last updated on May 24, 2022