What is Hypercalcemia Induced Tubulointerstitial Disease?

Hypercalcemia Induced Tubulointerstitial Disease
(A) Pre-treatment granulomatous interstitial nephritis (H & E, low power), arrow demonstrating granuloma. (B) Pre-treatment granulomatous interstitial nephritis granuloma (H & E, high power). (C and D) Post-treatment with adalimumab showing an intact glomerulus with diabetic changes, marked tubular atrophy, minimal interstitial inflammation, and complete disappearance of granulomas (H & E, low power). Treatment of sarcoid granulomatous interstitial nephritis with adalimumab: Gupta R, Beaudet L, Moore J, Mehta T - NDT plus (2009). Not altered. CC.

Hypercalcemia induced tubulointerstitial disease is the disease of the interstitium that is caused by increased levels of calcium in the body.

What is the Pathology of Hypercalcemia Induced Tubulointerstitial Disease

The pathology of hypercalcemia induced tubulointerstitial disease is:

-Etiology: The cause of hypercalcemia induced tubulointerstitial disease is increased calcium levels, 

-Genes involved: Unknown. 

-Pathogenesis: The sequence of events that lead to hypercalcemia induced tubulointerstitial disease is that too much calcium in the kidneys cause damage to the tubulointerstitial layers leading to nephropathy.

-Morphology: Not applicable. 

-Histology: The histology associated with hypercalcemia induced tubulointerstitial disease shows eosinophilic cellular infiltration, fibrosis and atrophy.inflammatory infiltrate with no glomerular changes. 

How does Hypercalcemia Induced Tubulointerstitial Disease Present? 

Patients with hypercalcemia induced tubulointerstitial disease typically are female and the age range is not clearly stated. The symptoms, features, and clinical findings associated with hypercalcemia induced tubulointerstitial disease include polyuria, dehydration, renal stones, hematuria, 

How is Hypercalcemia Induced Tubulointerstitial Disease Diagnosed? 

Hypercalcemia induced tubulointerstitial disease is diagnosed with renal biopsy, urinalysis, blood count, radiography and ultrasonography, CT scan.

How is Hypercalcemia Induced Tubulointerstitial Disease Treated? 

Hypercalcemia induced tubulointerstitial disease is treated with dialysis, transplantation.

What is the Prognosis of Hypercalcemia Induced Tubulointerstitial Disease?

The prognosis of hypercalcemia induced tubulointerstitial disease is fair but it will mostly depend on the management of the symptoms but the chances of it causing end stage renal failure is high.