What is Leiomyoma?

Leiomyoma
(A) Histological mapping of the resected specimen shows severe dysplasia with a leiomyoma. The black lines indicate the cutting line of the block sections. The yellow circle corresponds to the leiomyoma and the red squares correspond to atypical squamous cells. The lateral margin is positive in section 2 (arrow). (B) There are two sections: section 1 is composed of leiomyoma and severe squamous cell dysplasia on the lateral portion (red arrow), and section 2 shows the positive lateral margin (H&E stain, ×12.5). (C) The positive margin can be seen when the black circle in Fig. 5B is magnified (H&E stain, ×100). (D) The specimen with the lesion is histologically diagnosed after resection as high-grade intraepithelial squamous neoplasia (H&E stain, ×40). (E) The esophageal leiomyoma is strongly and diffusely positive for smooth muscle actin (×40). (F) The esophageal leiomyoma is positive for desmin (×40). Superficial Esophageal Neoplasms Overlying Leiomyomas Removed by Endoscopic Submucosal Dissection: Case Reports and Review of the Literature.Seo M, Kim do H, Cho YW, Gong EJ, Lee S, Choi E, Jung HY, Kim JH - Clinical endoscopy (2015). Not Altered. CC.

Leiomyoma is the bland smooth muscle tumor without mitotic figures.

What is the Pathology of Leiomyoma?

The pathology of leiomyoma is:

-Etiology: The cause of leiomyoma is ischemia or hormonal stimulation.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to leiomyoma is not well understood.

-Morphology: The morphology associated with leiomyoma shows monotonous spindle cells with indistinct borders arranged in intersecting fascicles.

-Histology: The histology associated with leiomyoma shows bundles or fascicles of spindled cells with eosinophilic and possibly fibrillary cytoplasm.

How does Leiomyoma Present?

Patients with leiomyoma typically affect women present in the age range of  40 and above (postmenopausal). The symptoms, features, and clinical findings associated with leiomyoma include menorrhagia, pelvic pain, pelvic pressure, frequent urination, heavy menstrual bleeding, and difficulty emptying the bladder.

How is Leiomyoma Diagnosed?

Leiomyoma is diagnosed using ultrasound and MRI.

How is Leiomyoma Treated?

Leiomyoma is treated with hysterectomy or myomectomy.

What is the Prognosis of Leiomyoma?

The prognosis of leiomyoma is excellent as the patient remains asymptomatic for many years or indefinitely. 

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Last updated on May 23, 2022