What is Wegener Granulomatosis?

Wegener Granulomatosis

a Nasal sarcoidosis. Irregular, pale epithelioid cell granulomas are surrounded by small lymphocytes. b Granulomatosis with polyangiitis (Wegener). Poorly formed epithelioid and multinucleate cell granulomas are associated with small lymphocytes. c Granulomatosis with polyangiitis (Wegener). Disruption of the wall of this small mucosal vessel is seen on H&E staining and d on staining for elastic tissue (EVG)Non-infectious Inflammatory Lesions of the Sinonasal Tract. Helliwell TR - Head and neck pathology (2016). Not Altered. CC.

Wegener Granulomatosis is a disease condition that causes the inflammation of the blood vessels.

What is the Pathology of Wegener Granulomatosis?

The pathology of Wegener granulomatosis is staphylococcus aureus was hypothesized as the initiating factor of the autoimmune disorder found in patients. Microscopically, inflammation of blood vessels with poorly formed granulomas.

How does Wegener Granulomatosis Present?

Wegener granulomatosis presents with irritation and inflammation of the nose, scleritis, conjunctivitis, glomerulonephritis, hearing loss, arthritis, and subglottic stenosis.

How is Wegener Granulomatosis Diagnosed?

Wegener granulomatosis is diagnosed by Upper respiratory tract tissue biopsy, kidney biopsy, antineutrophil cytoplasmic antibody test (ANCA).

How is Wegener Granulomatosis Treated?

Wegener granulomatosis is treated with Plasmapheresis, administration of rituximab, cyclophosphamide.

What is the Prognosis of Wegener Granulomatosis?

The prognosis of Wegener granulomatosis is with the ancient treatment, life expectancy was less than 5yrs, with modern treatment, patients can live 20+ years after treatment.

Wegener Granulomatosis

Last updated on May 23, 2022