What is Pancreatic Carcinoid Tumor?

Pancreatic Carcinoid Tumor
Pancreatic Carcinoid Tumor. Hematoxylin and eosin (HE) and specific immunohistochemical staining for NSE, Syn, CgA, and CK in samples from patient no. 3, a 46-year-old female, with a one-month history of backache. (A) HE, ×100 magnification; (B) HE, ×400 magnification; (C) NSE+++, ×200 magnification; (D) CK++, ×200 magnification; (E) CgA+, ×200 magnification; and (F) Syn+, ×200 magnification. Tumor cells with identical shape, regular arrangement, and abundant cytoplasm were observed. Fine particles, and small and round nuclei were found in the middle of the cells by eosin staining. Chromatin was fine and uniform. Nuclear fission was often apparent. NSE, CK, CgA, and Syn particles were located in the plasma of the tumor cells, with no expression in the intercellular substance. Computed tomography indicated that the mass was 4.5 cm3 and located on the tail of the pancreas. Distal pancreatectomy was performed. This patient was followed up until August 2011, with no signs of metastasis for 21 months. NSE, neuron-specific enolase; CK, cytokeratin; CgA, chromogranin A; Syn, synaptophysin. Clinical characteristics and prognosis of primary pancreatic carcinoid tumors: A report of 13 cases from a single institution: Liu FH, Wang C, Xing YL, Wu JH, Tang Y - Oncology letters (2014). Not altered. CC.

Pancreatic carcinoid tumor is a rare tumor of the pancreas that usually presents with carcinoid syndrome, which is characterized by diarrhea, valvular disease, cutaneous flushing.

What is the Pathology of Pancreatic Carcinoid Tumor?

The pathology of pancreatic carcinoid tumor is:

-Etiology: The cause of pancreatic carcinoid tumor is not known

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to pancreatic carcinoid tumor are not known.

-Morphology: The morphology associated with pancreatic carcinoid tumor shows a polypoid mass.

-Histology: The histology associated with pancreatic carcinoid tumor shows distinctive patterns: trabecular or ribbons; solid, nodular, and insular cords; ill differentiated or atypical forms; tubules and glands or rosettelike forms;  and assorted patterns.

How does Pancreatic Carcinoid Tumor Present? 

Patients with pancreatic carcinoid tumor typically have no gender prevalence present at an age range of 20 years and above. The symptoms, features, and clinical findings associated with pancreatic carcinoid tumor include abdominal pain, cutaneous flushing, and pellagra skin lesions.

How is Pancreatic Carcinoid Tumor Diagnosed? 

Pancreatic carcinoid tumor is diagnosed through laboratory testing which includes biomarkers and biogenic amine levels. Imaging studies plain radiography, CT scan, ultrasound, MRI, and angiography.

How is Pancreatic Carcinoid Tumor Treated? 

Pancreatic carcinoid tumor is treated through chemotherapy and surgical interventions.

What is the Prognosis of Pancreatic Carcinoid Tumor?

The prognosis of pancreatic carcinoid tumors is fair.

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Last updated on May 23, 2022