What is Neuropathy Associated with Vasculitis?

Neuropathy Associated with Vasculitis
Neuropathy Associated with Vasculitis. Histopathology findings of a sural nerve biopsy. A: Extensive infarct of the peripheral nerve and Schwann cells (hematoxylin-eosin stain, original magnification ×40). B: Endoneurial capillary ectasia and congestion with hemorrhage (hematoxylin-eosin stain, original magnification ×200). C: Intravascular thrombosis with mild lymphocytic infiltration present in the epineurium. There was no definite neutrophilia or leukocytoclasia, suggesting vasculitis (i: hematoxylin-eosin stain, ii: leukocyte common antigen stain, original magnification ×200). D: Electron micrograph showing marked degeneration of axons and their myelin sheath, with the Schwann cell cytoplasm containing many autophagic vacuoles and myelin figures. Ischemic neuropathy associated with livedoid vasculitis: Kim JE, Park SY, Sinn DI, Kim SM, Hong YH, Park KS, Sung JJ, Lee KW - Journal of clinical neurology (Seoul, Korea) (2011). Not altered. CC.

Neuropathy associated with vasculitis is part of systemic vasculitis presenting with either mononeuritis multiplex or asymmetric sensorimotor neuropathy. 

What is the Pathology of Neuropathy Associated with Vasculitis?

The pathology of neuropathy associated with vasculitis is:  

-Etiology: The cause of neuropathy associated with vasculitis is blood vessel defects.

-Genes involved: NA.

-Pathogenesis: The sequence of events that lead to neuropathy associated with vasculitis results after ischemic infarction instigated by inflammatory constriction of the blood vessels.

-Morphology: NA.

-Histology: NA.

How does Neuropathy Associated with Vasculitis Present? 

Patients with neuropathy associated with vasculitis typically affect both genders equally present at age range 30 to 60 years. The symptoms, features, and clinical findings associated with neuropathy associated with vasculitis include myalgias, fevers, weight loss, fatigue, arthralgias, anorexia, and poorly localized acute pain.

How is Neuropathy Associated with Vasculitis Diagnosed? 

Neuropathy associated with vasculitis is diagnosed through laboratory studies-ESR> 20 mm/h, elevated antinuclear antibody titer, rheumatoid factor, renal function test, serum complement. Other studies that may be helpful include imaging studies, electromyography, and nerve conduction studies.

How is Neuropathy Associated with Vasculitis Treated? 

Neuropathy associated with vasculitis is treated through medical care- immunosuppressive agent, corticosteroids and cyclophosphamide therapy.

What is the Prognosis of Neuropathy Associated with Vasculitis?

The prognosis of neuropathy associated with vasculitis is poor.