What are Malignancy Associated Neuropathies?

Malignancy Associated Neuropathies
Malignancy Associated Neuropathies. Nodular sclerosing pattern of Hodgkin’s lymphoma. Hodgkin's lymphoma presenting as a complex paraneoplastic neurological syndrome: a case report: Ammannagari N, Chikoti S, Bravin E - Journal of medical case reports (2013). Not altered. CC.

Malignancy associated neuropathies are diseases of the nervous system that occur as a result of pre-existing malignancies in the individual and the medication that is used to manage their neuropathies.

Examples of malignancy associated neuropathies include:

  • Neuropathy due to chemotherapy side effects
  • Neuropathy due to monoclonal gammopathies
  • Neuropathy due to tumor compression
  • Neuropathy due to tumor infiltration
NEUROPATHIES ASSOCIATED WITH MALIGNANCY   
NEUROPATHYSIGNS/ SYMPTOMSTREATMENTPROGNOSIS
Chemotherapy side effects neuropathyTingling sensation, burning sensation, stabbing pain, and complete numbness.Steroids, antiseizure drugs, opioids, antidepressantsGood prognosis since once the chemotherapy is withdrawn then symptoms disappear.
Monoclonal gammopathies neuropathySensory ataxia, tingling sensation, and numbness.plasmapheresisFair since the side effects occurs ten years later and the mortality rate is low
Tumor compression neuropathyLoss of function, numbness, weakness, loss of balance Removal of the tumor. 
Tumor infiltration neuropathy   
Malignancy associated neuropathies.