Disorders of Epidermal Maturation. Representative case of Bowen’s disease, with full-thickness involvement of the epidermis by dysplastic keratinocytes. Solar elastosis and chronic inflammation are present in the superficial dermis. Hematoxylin-eosin, original magnification × 200. Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen's disease: Švajdler M, Mezencev R, Kašpírková J, Kacerovská D, Kazakov DV, Ondič O, Michal M - Diagnostic pathology (2016). Not altered. CC.