Erythema multiforme is an uncommon, usually self-limited disorder that appears to be a hypersensitivity response to certain infections and drugs.

What is the Pathology of Erythema Multiforme?

The pathology of erythema multiforme is:  

-Etiology: The cause of erythema multiforme is herpes virus (HSV), drug hypersensitivity, contact exposure.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to erythema multiforme are multifactorial.

-Morphology: The morphology associated with erythema multiforme shows a characteristic “targetoid” or “bulls eye”appearance.

-Histology: The histology associated with erythema multiforme shows superficial perivascular, lymphocytic infiltrate.

How does Erythema Multiforme Present? 

Erythema multiforme typically affects more males than females present at an age range of 5 to 45 years. The symptoms, features, and clinical findings associated with erythema multiforme include nonspecific URTI, and sudden onset of a rash.

How is Erythema Multiforme Diagnosed? 

Erythema multiforme is diagnosed with clinical examination and history taking. Laboratory studies- CBC count with moderate leukocytosis, BUN, and creatinine test, immunofluorescence, PCR, biopsy. 

How is Erythema Multiforme Treated? 

Erythema multiforme is treated through medical care- symptomatic management, oral, analgesics, antihistamines local skincare, soothing mouthwashes, rehydration, and nutrition support. Pulmonary support according to severity.

What is the Prognosis of Erythema Multiforme?

The prognosis of erythema multiforme is good the condition is self-limiting.