Neoplasms of Spleen. Spleen immunohistochemistry. Notes: (A) and (B) Expression of CD20 by the neoplastic infiltrate. (C) igD staining showing positive neoplastic cells. (D) Ki67/Mib-1 highlighting the higher proliferation indexes in the germinal center and outer zone (targetoid/biphasic pattern). Abbreviation: igD, immunoglobulin D. Not altered. CC. Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management Larissa Sena Teixeira, Mendes, Ming-Qing Du, Estella Matutes, Andrew Wotherspoon