Different types of copy number variations (CNVs) and an example of genome-wide detection of CNVs. Upper plot illustrates relative deletion, duplication, and multiple segmental duplication of the " D " locus compared with the reference genome . Inversion of " C " and " D " loci is also illustrated. The lower plot shows an example of genome-wide CNV detection using oligoarray-comparative genomic hybridization. Red and blue arrows represent copy number gain-and loss-CNVs, respectively. Not altered. CC. Clinical implications of copy number variations in autoimmune disorders Seon-Hee Yim, Seung-Hyun Jung, Boram Chung, and Yeun-Jun Chung