Table of Immunodeficiency Disorders

No.	Disease	Causes	Symptoms	Diagnosis	Treatment	Prognosis
1	X-linked Agammaglobulinemia	Bruton tyrosine kinase deficiency causes a failure of B cell development	meningitis, bronchitis, pneumonia, sepsis, infections	PCR)-based single-strand conformation polymorphism (SSCP).	Immunoglobulin replacement therapy, oral antibiotics to treat infections	good
2	Common Variable Immunodeficiency	Mutations in the genes which result in dysfunctional B cells	Breathing problems, chronic cough, diarrhoea, lung infections, pneumonia	immunofluorescence staining,	Ig replacement therapy	reasonably good
3	IgA Deficiency	intrinsic defects in B cells, anomalies in Th-cell,	frequent infections or NO symptoms	blood screening for IgA levels	Prophylactic antibiotics for infections	good
4	Hyper-IgM Syndrome	a variation in the CD40LG gene, X-linked recessive mutation	Tachypnea, bluish discoloration (cyanosis) of the skin	flow cytometry, molecular genetic testing	immunoglobulin replacement therapy	Poor
5	DiGeorge Syndrome	deletion of part of the long arm of chromosome 22	underdeveloped chin, low-set ears, wide-set eyes or a narrow groove in the upper lip	FISH analysis	thymus tissue transplant, abnormalities surgically repaired, antibiotics	Depends on severity
6	Severe Combined Immunodeficiency	genetic defects affecting the function of T cells	frequent, often serious respiratory infections, chronic diarrhoea	multiple blood tests, flow cytometry, DNA sequencing	bone marrow transplant	Poor
7	Wiskott–Aldrich syndrome	defect in the WAS gene	eczema arthritis, inflammatory bowel disease, nephritis, vasculitis	Blood tests, DNA sequencing, flow cytometry, quantitative Ig levels	stem cell transplant, antibiotics	Poor
8	Ataxia Telangiectasia	ATM gene Mutation on chromosome 11	Decreasing mental development, Seizures, Severe respiratory infections recurring	Serum Ig levels, gene sequencing, X-rays	symptomatic treatments	good
9	AIDS	human immunodeficiency virus (HIV)	severe fatigue, genital or anal sore, regular coughing and breathing problems, fever	ELISA Test	antiretroviral therapy to protect CD4 cells	Poor