Secondary Hemostasis

Secondary Hemostasis Pathology Study Guide

Secondary Hemostasis The whole point of secondary hemostasis is to stabilize the platelet plug. The main end product of the coagulation cascade is thrombin. Secondary hemostasis utilizes the coagulation cascade to stabilize the frail platelet plug. The fibrinogen in the…
THE PATHOLOGY OF HEMOSTASIS

Other Disorders of Hemostasis Pathology Study Guide

Heparin Induced Thrombocytopenia Heparin induced thrombocytopenia is the destruction of platelets that results from heparin therapy. Heparin induced thrombocytopenia (HIT) is an immune complication due to antibodies directed against complexes containing heparin and a platelet factor 4 (PF4). Platelet fragments…
Virchow’s Triad

Thrombosis and Embolism Pathology Study Guide

Thrombosis Pathologic development of an intravascular blood clot may result in a thrombus. Thrombosis may occur in arteries and/or veins. The deep veins in the leg below the knee are where they are most frequently found. Ante-mortem thrombosis is characterized…
Hemostasis

Hemostasis Pathology Study Guide

Hemostasis The body's natural response to an injury that stops the bleeding and fixes the damage is known as hemostasis. Blood must be able to flow freely through blood vessels in order to reach tissues. Hemostasis, which involves the creation…
Primary Hemostasis

Primary Hemostasis Pathology Study Guide

Primary Hemostasis Step 1: Transient Vasoconstriction of Damaged Vessel A vascular spasm is activated which leads to vasoconstriction. The vascular spasm is mediated by: Neural reflex Contraction of endothelial cells due to endothelin being released from neighboring endothelial cells that…