Multiple Myeloma

Plasma Cell Disorder Pathology Study Guide

Plasma Cell Disorders (Dyscrasias) Plasma cell disorders are also known as plasma cell dyscrasias. Examples of plasma cell disorders include: Multiple myeloma (MM) Monoclonal gammopathy of undetermined significance (MGUS) Waldenstrom macroglobulinemia (WM) Multiple Myeloma Multiple myeloma (MM) is a malignant…
Pulmonary Langerhans Cell Histiocytosis

Langerhans Cell Histiocytosis Pathology Study Guide

Langerhans Cell Histiocytosis The skin is the primary location of Langerhans cells, which are specialized dendritic cells. Langerhans cells are derived from bone marrow monocytes.  Langerhans cells present antigen to naive T cells A neoplastic growth of Langerhans cells is…
Splenic Marginal Zone Lymphoma

Lymphoma Pathology Study Guide

Lymphadenopathy (LAD) Large lymph nodes are referred to as lymphadenopathy (LAD). Typically, lymph nodes that are draining an area of acute infection show painful lymphadenopathy (acute lymphadenitis). Causes of lymphadenopathy include: Benign lymph node hyperplasia Reactive lymph node Acute inflammation…
Increased Reticulin in Marrow in Myeloproliferative Disorder

Myeloproliferative Disorders Pathology Study Guide

Myeloproliferative Disorders Myeloproliferative disorders are neoplastic proliferation of myeloid cells. Myeloproliferative disorders typically occur in late adulthood (average age is 55-years-old). Myeloproliferative disorders are associated with: Leukocytosis (high white blood cell count) Hypercellular bone marrow In myeloproliferative disorders there is…
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Chronic Leukemia Pathology Study Guide

Chronic Leukemia Chronic leukemia involves leukemia of mature blood cells. Chronic leukemia is typically insidious in onset and visible in elderly adults. Examples of chronic leukemias include: Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) Hairy cell leukemia (HCL) Adult T-cell leukemia/lymphoma…
T-cell Acute Lymphoblastic Leukemia/Lymphoma (T-ALL)

Acute Leukemia Pathology Study Guide

Acute Leukemia Acute leukemia is the neoplastic proliferation of blast cells. The abnormal blood cells in acute leukemia are immature blood cells called blasts.  Acute leukemia is defined as the accumulation of greater than 20% blasts in the bone marrow.…
Leukopenia

Leukopenia and Leukocytosis Pathology Study Guide

Leukopenia and Leukocytosis Hematopoiesis is a stepwise maturation of CD34+ hematopoietic stem cells. From the bone marrow, hematopoietic cells develop and are released into the blood. A white blood cell (WBC) count of 5,000 - 10,000 WBCs per microliter is…