What are Adhesions?

Adhesions
A schematic model depicting the structure of focal adhesion and paxillin staining. (A and B) Fluorescent photomicrograph of human MSC showing the immuno-histological detection of paxillin, a multi-domain adaptor that recruits both structural and signalling molecules to focal adhesions (see gray outline in B). Primary anti-paxillin antibody (Cat. no. 1500-1, Epitomics, USA) was combined with secondary Alexa Fluor 488 antibody (in green), (Cat. no. A11034, Molecular Probes, Germany). Actin fibres and nucleus were stained respectively with Phalloidin (in red), (Cat. no. H-22284, Molecular Probes, Germany) and DAPI (in blue), (Cat. no. D1306, Molecular Probes, Germany). Bars: 50 μm (C) Focal adhesions are sites, where the heterodimeric (and) integrin receptors (depicted by the red and blue larger forms) engage with an extracellular matrix (ECM) protein (the shape in pink) and a cascade of integrin-, membrane-, actin- and signalling-associated molecules (represented as multi-colour dots). Besides having central roles in cell motility and cytoskeletal dynamics, focal adhesions convey information across the cell membrane to regulate cell proliferation, differentiation, gene expression and survival. Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system. Docheva D, Popov C, Mutschler W, Schieker M - Journal of cellular and molecular medicine (2007 Jan-Feb). Not Altered. CC.

Adhesions are bands of scar tissue that form between abdominal organs, mainly the small intestine. Adhesions occur after abdominal surgery and can cause your tissues to stick together.

What is the Pathology of Intestinal Adhesions?

The pathology of intestinal adhesions is:

-Etiology: The cause of intestinal adhesions is tissue incisions, contact of internal tissues with foreign materials, such as gauze, surgical gloves, and stitches.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to intestinal adhesions are: bands of fibrous tissue in the abdominal cavity that can form after abdominal or pelvic surgery, the inflammation occurs on the surface of the organ; the formation of scar tissue is a normal part of healing during inflammation. The fibrous bands are formed between tissues and organs.

-Histology: The histology associated with intestinal adhesions shows sticked scar tissues together.

How does Intestinal Adhesions Present?

Patients with intestinal adhesions typically in all genders present at any age. The symptoms, features, and clinical findings associated with intestinal adhesions include constipation, blotting, abdominal pain, nausea, and vomiting.

How is Intestinal Adhesions Diagnosed?

Intestinal adhesions is diagnosed by laparoscopy, and cannot be detected by tests or seen through imaging techniques such as x rays or ultrasound.

How is Intestinal Adhesions Treated?

Intestinal adhesions are typically not treated unless they are complications. If abdominal adhesions cause symptoms or complications, doctors can release the adhesions with laparoscopic or open surgery.

What is the Prognosis of Intestinal Adhesions?

The prognosis of intestinal adhesions is good but if adhesions cause intestinal obstruction, which then they could be life-threatening.

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Last updated on May 26, 2022