What are Coagulation Factor Defects?

Coagulation Factor Defects
Schematic illustrating the potential effects of antiplatelet or anti-NET treatments in infection-induced coagulopathy. Treatments (red crossed-out boxes) that act to limit pathogen-induced platelet aggregation or that block/degrade NETs may substantially limit the ability of infection-induced inflammation to drive coagulation. These therapies aim to limit the uncontrolled amplification of coagulation while protecting the ability of individual platelets to respond to pathogens or to vascular damage. By limiting platelet and NET-mediated amplification of coagulation during systemic inflammation, one might be able to restore balance to the coagulation system, preserving hemostasis while mitigating coagulopathy. Platelets and coagulation in infection. Davis RP, Miller-Dorey S, Jenne CN - Clinical & translational immunology (2016). Not Altered. CC.

Coagulation factor defects are abnormalities in coagulation factors that may alter the clotting process.

What is the Pathology of Coagulation Factor Defects?

The pathology of coagulation factor defects is:

-Etiology: The cause of coagulation factor defects is typically an inherited defect in the factor’s gene.

-Pathogenesis: The sequence of events that lead to coagulation factor defects are related to the specific factor that is defective.

-Morphology: The morphology associated with coagulation factor defects shows heavy and prolonged bleeding after an injury, bruising, and epistasis.

How do Coagulation Factor Defects Present?

Patients with coagulation factor defects typically are either male or female present at the age range of infants. The symptoms, features, and clinical findings associated with coagulation factor defects include bruising, and easy bleeding.

How are Coagulation Factor Defects Diagnosed?

Coagulation factor defects are diagnosed with specialized tests, and possibly genetic tests.

How are Coagulation Factor Defects Treated?

Coagulation factor defects are typically treated by replacing the defective factor with functional factors.

What is the Prognosis of Coagulation Factor Defects?

The prognosis of coagulation factor defects is good.

Tags:
Last updated on May 24, 2022