Defects in lymphocyte maturation are failure of development of lymphocytes from their progenitor in bone marrow or thymus which result in decreased T cells or B cells. Examples of defects in lymphocyte maturation include autosomal severe combined immunodeficiency disease (SCID), recombination activating gene (RAG) deficiency.
What are Defects in Lymphocyte Maturation?
Schematic of TAM receptor expression in hematopoietic cells. Differential expression of TAM receptors in the hematopoietic system is shown. AXL protein and mRNA are expressed in bone marrow stromal cells. MERTK and AXL are expressed in CD34+ hematopoietic progenitors and some stages of myeloid development including erythrocyte precursors in the bone marrow. All TAM receptors are present in megakaryocytes, mature platelets, tissue macrophages, and dendritic cells. MERTK is expressed in bone marrow monocytic precursors and tissue macrophages but not in circulating monocytes. Although TAM receptors are not expressed in lymphoid progenitors or mature lymphocytes, they are highly expressed in NK and NKT cells. Targeting the TAM Receptors in Leukemia. Cancers. Not Altered. CC.
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What are Defects in Adaptive Immunity?