Pathology of an Active Biopsied multiple sclerosis Lesion. Biopsies from all 168 cases demonstrated the characteristic features of active inflammatory demyelinating disease consisting of hypercellular lesions with myelin loss (A; Luxol-fast blue and periodic acid Schiff), reactive gliosis (B; haematoxylin–eosin), Creutzfeldt cells (C; haematoxylin–eosin), lipid-laden macrophages (D and E; immunocytochemistry for proteolipid protein) and relative axonal preservation (F; Bielschowsky silver impregnation).Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis.
Lucchinetti CF, Gavrilova RH, Metz I, Parisi JE, Scheithauer BW, Weigand S, Thomsen K, Mandrekar J, Altintas A, Erickson BJ, König F, Giannini C, Lassmann H, Linbo L, Pittock SJ, Brück W - Brain : a journal of neurology (2008). Not Altered. CC.
Demyelinating diseases are conditions that result in damage to the myelin sheath that surrounds nerve fibers. Damage to the myelin sheath can result in delayed or even absent transmission of nerve impulses which may present as neurological problems.
Examples of demyelinating diseases include:
- Acquired degeneration of myelin
- Multiple sclerosis
- Neuromyelitis optica
- Acute disseminated encephalomyelitis
- Acute necrotizing hemorrhagic encephalomyelitis
- Central pontine myelinolysis
