Familial Cancer Syndromes with Skin Manifestations. Photomicrographs. (a) Haematoxylin and Eosin stain (100×) of a hamartomatous polyp from the descending colon showed proliferation of dilated mucinous glands surrounded by smooth muscle fibers. This latter feature is characteristic of hamartomatous polyps observed in patients with Peutz-Jegher syndrome. (b) Photomicrograph of the left kidney tumor was composed of a solid proliferation of spindle cell with large irregular nucleus, abundant cytoplasm, and prominent mitotic figures. The findings are consistent with a high-grade clear cell renal cell carcinoma, sarcomatoid type.A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. Mai PL, Korde L, Kramer J, Peters J, Mueller CM, Pfeiffer S, Stratakis CA, Pinto PA, Bratslavsky G, Merino M, Choyke P, Linehan WM, Greene MH - Journal of medical case reports (2007). Not Altered. CC.
Familial cancer syndromes with skin manifestations are genetic disorders where there is inheritance of mutated genes which manifest in an individual.
Examples of familial cancer syndromes with skin manifestations include:
- Ataxia-telangiectasia
- Cowden syndrome
- Familial melanoma syndrome
- Nevoid basal cell carcinoma syndrome
- Muir-Torre syndrome
- Neurofibromatosis type 1
- Neurofibromatosis type 2
- Tuberous sclerosis
- Xeroderma pigmentosum
