Different Examples of Cryobiopsy Showing UIP pattern.A) A low-magnification image showing dense scarring obliterating the alveolar architecture and abruptly alternating with relatively normal lung (patchy fibrosis). Some fibroblastic foci are visible even at this magnification for their pale-gray color. B) Fibroblastic focus better visualized at higher magnification. C) An area of honeycombing. Transbronchial lung cryobiopsy in the diagnosis of fibrotic interstitial lung diseases. Casoni GL, Tomassetti S, Cavazza A, Colby TV, Dubini A, Ryu JH, Carretta E, Tantalocco P, Piciucchi S, Ravaglia C, Gurioli C, Romagnoli M, Gurioli C, Chilosi M, Poletti V - PloS one (2014). Not Altered. CC.