(A) Human lung with focal areas of necrosis and syncytia formation (black arrow) on day 3 post infection (10× magnification). (B) Human lung with extensive areas of necrosis, syncytia formation and loss of architecture on day 10 post infection (10× magnification). (C) Bronchi with syncytia formation (*) on day 3 post infection (20× magnification). (D) Loss of alveolar architecture and areas of necrosis (black arrow) on day 10 post infection (20× magnification). (E) Alveolar space with syncytial formation (*) on day 3 post infection (40× magnification). (F) Pulmonary vasculature with syncytial formation (*) on day 3 post infection (40× magnification), fibrinoid necrosis of the intima, and influx of granulocytes (black arrowhead). A human lung xenograft mouse model of Nipah virus infection: Valbuena G, Halliday H, Borisevich V, Goez Y, Rockx B - PLoS pathogens (2014). Not altered. CC.