Lysosomes. Lysosomes are in close proximity to the sarcoplasmic reticulum (SR) in rabbit ventricular myocytes, forming nanojunctions.(A,B) Representative examples of lysosomes (L) in close proximity to the SR. (C) Population data showing the shortest distance from a lysosomal-related organelle membrane to the nearest SR membrane. Median distance 20 nm (13–24 nm), n = 56. High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart. Aston D, Capel RA, Ford KL, Christian HC, Mirams GR, Rog-Zielinska EA, Kohl P, Galione A, Burton RA, Terrar DA - Sci Rep. (2017). Not Altered. CC.