IHC staining of FHIT and FISH signals for HPV and FHIT.(A)-(C) typical FHIT staining in normal cervix (A), CIN (B) and cervical cancer (C) (×200). (D) HPV signals in cervical cancer (shown in red) (×1000). (E) and (F) FHIT signal variation in CIN (E) and cervical cancer (F) (shown in green) (×1000). Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad ( FHIT ) predicts the transition of cervical lesions. PLoS ONE. Not Altered. CC.