SOX2 knock down reduced in vivo metastasis of colorectal cancer cells in mice.(A) HE staining of mice lung tissue containing metastasis. (B) HE staining of mice liver tissue containing metastasis. (C) HE staining of mice lung tissue without metastasis. (D) HE staining of mice liver tissue without metastasis. (E) SOX2 staining of the lung metastasis with the arrow indicating strong staining of SOX2 in the invasive frontal regions. (F). SOX2 staining of the mouse lung tissue without metastasis. All images are in 100×.Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients. Han X, Fang X, Lou X, Hua D, Ding W, Foltz G, Hood L, Yuan Y, Lin B - PloS one (2012). Not Altered. CC.