Mitochondria. Electron photomicrographs of mitochondria (scale bars: 200 nm).(A) Normal mitochondria: following fixation, intact membranes and dense matrix space were observed (arrows).(B) Control group: incubation with CaCl2 induced mitochondrial swelling, separated inner and outer mitochondrial membrane, ruptured cristae, and a non-dense matrix was observed (arrows).(C) Ruthenium red group: some comparatively intact membranes and dense matrix space were also observed (arrows).(D) Spermine group: separated inner and outer mitochondrial membrane, ruptured cristae, and a non-dense matrix space were clearly observed (arrows).(E) Cyclosporine A plus spermine group: the degree of swelling (arrows) was similar to that of the control group. The calcium uniporter regulates the permeability transition pore in isolated cortical mitochondria. Yu N, Wang S, Wang P, Li Y, Li S, Wang L, Chen H, Wang Y - Neural regeneration research (2012). Not Altered. CC.