Muscle biopsy. (A) H&E staining of a muscle biopsy of the left anterior tibial muscle with mild myopathic changes indicated by muscle fiber splitting and increase in endomysial connective tissue. Additionally, in the ATPase pH 4.1 staining (B), a type I fiber predominance without evidence of fiber type grouping and numerous hypertrophic type I fibers are notable. Bars in A and B adjusted to 50 μm. Facioscapulohumeral muscular dystrophy and Charcot-Marie-Tooth neuropathy 1A - evidence for "double trouble" overlapping syndromes. Schreiber O, Schneiderat P, Kress W, Rautenstrauss B, Senderek J, Schoser B, Walter MC - BMC medical genetics (2013). Not Altered. CC.