Anti-ubiquitin immunostaining in neurodegenerative disease. Ubiquitin antibodies highlight Alzheimer disease pathology including hippocampal plaques (a) and neurofibrillary tangles (b). Brain stem (c) and cortical Lewy bodies (d) are also ubiquitin positive. Ubiquitin-positive inclusions are found in the nucleus of cortical neurons in Huntington disease (e) and in the cytoplasm of anterior horn neurons in motor neuron disease (f). Original magnifications are ×200 (a, b) and ×400 (c–f). The ubiquitin proteasome system in neuropathology. Lehman NL - Acta neuropathologica (2009). Not Altered. CC.