Pancreatic Neuroendocrine Tumors. a Macroscopic appearance of pancreatic neuroendocrine tumor showing a well-demarcated pinkish tumor surrounded by normal pancreatic parenchyma. b Pancreatic neuroendocrine tumor, detail showing typical salt and pepper chromatin. c Loss of Menin expression in pancreatic neuroendocrine tumor indicative of MEN1 gene inactivation. d Retained Menin expression in pancreatic neuroendocrine tumor with a wildtype MEN1 gene. Surgical and molecular pathology of pancreatic neoplasms.
Hackeng WM, Hruban RH, Offerhaus GJ, Brosens LA - Diagnostic pathology (2016). Not Altered. CC.
Pancreatic neuroendocrine tumors are diseases of abnormal cell growth that arise from the islet cells of the pancreas.
Examples of Pancreatic Neuroendocrine Tumors include:
- Gastrinoma
- Glucagonoma
- Insulinoma
- Pancreatic carcinoid tumor
- Pancreatic polypeptide-secreting endocrine tumors
- Somatostatinoma
- VIPoma
