Effect of IL-1Ra on neuronal morbidity and mortality of LPS+HI exposed pups. IL-1Ra decreased the percentage of mortality of pups (all the mortality of rats occurred during hypoxia, between 1 and 1 h 30 min of hypoxia) (a) and the right hemisphere percentage of tissue loss in forebrains exposed to LPS+HI (b). Macroscopic view of brain damage at P20 by H&E stained on coronal sections of pup exposed to LPS+HI ± IL-1Ra (c). Core lesions are indicated by asterisks, and penumbra lesions are indicated by P. These lesions were reduced by IL-1Ra treatment. Error bars represent means ± SEM, scale bar = 50 μm, six to eight animals per condition, unpaired t test with Welch correction, * p ≤ 0.05, *** p ≤ 0.001. Abbreviations: H&E hematoxylin and eosin. Neuronal self-injury mediated by IL-1β and MMP-9 in a cerebral palsy model of severe neonatal encephalopathy induced by immune activation plus hypoxia-ischemia. Savard A, Brochu ME, Chevin M, Guiraut C, Grbic D, Sébire G - Journal of neuroinflammation (2015). Not Altered. CC.