What are Precursor B-Cell Neoplasms?

Precursor B-cell neoplasms are neoplasms involving lymphoblasts committed to the B-cell lineage.

An example includes B-cell acute lymphoblastic leukemia/lymphoma (B-ALL).

Morphology of the leukemic blasts in the cerebrospinal fluid at first relapse (A) and in the bone marrow at second relapse (B) (Wright-Giemsa stain, ×1,000). MYC rearrangement involving a novel non-immunoglobulin chromosomal locus in precursor B-cell acute lymphoblastic leukemia. Seo JY, Lee SH, Kim HJ, Yoo KH, Koo HH, Cho YG, Choi SI, Kim SH - Annals of laboratory medicine (2012). Not altered. CC.
Peripheral smear, Wright-Giemsa stain, 100x image showing an abnormal circulating lymphoid cell with the same cytology as the lymphoid cells in the bone marrow. Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report. Hirzel AC, Cotrell A, Gasparini R, Sriganeshan V - Case reports in pathology (2013). Not altered. CC.