What are Struma Ovarii Teratomas?

Struma Ovarii Teratomas
57-year-old female with struma ovarii. Prepared slides from the resected ovarian mass show thyroid follicles lined by a single layer of epithelium containing amorphous colloid material. Incidental scintigraphic detection of struma ovarii following total thyroidectomy for papillary thyroid cancer. Wagner CP, Hicks BN, Nakamura KM - Radiology case reports (2015). Not Altered. CC.

Struma ovarii teratomas are specialized or monodermal teratoma predominantly composed of mature thyroid tissue. 

What is the Pathology of Struma Ovarii Teratomas?

The pathology of struma ovarii teratomas is:

-Etiology: The cause of struma ovarii teratomas is unknown.

-Genes involved: BRAF gene.

-Pathogenesis: The sequence of events that lead to struma ovarii teratomas is unknown.

-Morphology: The morphology associated with struma ovarii teratomas shows peritoneal or pleural effusion mass.

-Histology: The histology associated with struma ovarii teratomas shows thyroid microfollicles with a single cell lining, overlapping nuclei, rare mitotic figures.

How does Struma Ovarii Teratomas Present?

Patients with struma ovarii teratomas typically females between 40-60 years age. The symptoms, features, and clinical findings associated with struma ovarii teratomas include: pain and/or a pelvic mass and less frequently with ascites, hyperthyroidism, absence of thyroid gland enlargement, an elevated thyroglobulin level. 

How is Struma Ovarii Teratomas Diagnosed?

Struma ovarii teratomas is diagnosed by: thyroid function tests, ultrasound, CT scan.

How is Struma Ovarii Teratomas Treated?

Struma ovarii teratomas is treated by: surgery, laparoscopy, hysterectomy with bilateral salpingo-oophorectomy in post menopausal women. 

What is the Prognosis of Struma Ovarii Teratomas?

The prognosis of struma ovarii teratomas is excellent. The prognosis of malignant type disease is not well-characterized, given the rarity of this disease.