What are Syringomas?

Syringomas
Syringomas. Biopsy specimen demonstrating typical syringoma features. (Left) Basal hyperpigmentation in the epidermis (Hematoxylin-eosin stain; original magnification × 4). (Right) Characteristic dermal coma-shaped structures lined by 2 rows of epithelial cells surrounded by collagen bundles, with colloidal material within the lumina (Hematoxylin-eosin stain; original magnification × 40). Surgical excision of multiple penile syringomas with scrotal flap reconstruction. Vaca EE, Mundinger GS, Zelken JA, Erdag G, Manahan MA - Eplasty (2014). Not Altered. CC.

Syringomas are mostly non-cancerous growths of the sweat glands. 

What is the Pathology of Syringomas?

The pathology of syringomas is: the study of the tumors that arise from the sweat glands.

-Etiology: The cause of syringomas is increased multiplication of the cells in the sweat glands and can be genetic and diabetes mellitus.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to syringomas is the overgrowth of the cells found in the sweat glands.

-Morphology: The morphology associated with syringomas shows clusters that are either brown, pink, or yellow, found mostly near the eyes. They are around 1-4 mm.

-Histology: The histology associated with syringomas shows numerous small ducts embedded in a stroma that is sclerotic with a margin that can be cuboidal to the flattened epithelial lining.

How does Syringomas Present? 

Patients with syringomas typically affect females more than males and appear mostly during puberty. The symptoms, features, and clinical findings associated with syringomas are very rare but some may have itchiness and pain.

How is Syringomas Diagnosed? 

The syringomas are diagnosed mainly by physical examination but a biopsy may be done to exclude it from other tumors. 

How is Syringomas Treated? 

The syringomas are treated using trichloroacetic acid which makes them fall off and surgery, laser removal, and electric cauterization. 

What is the Prognosis of Syringomas?

The prognosis of syringomas is good since they can be treated and if they recur it is also easy to treat them.