What are the Different Types of Systemic Lupus Erythematous?

Different Types of Systemic Lupus Erythematous
Histopathology of the skin lesion. (A, B) Histopathologic examination of the skin biopsy specimen showed a subepidermal blister with abundant neutrophils (H&E stain, × 100). (C) Direct immunofluorescence examination showed linear deposition of IgG at the dermo-epidermal junction (× 100).Methimazole-induced bullous systemic lupus erythematosus: a case report. Seo JY, Byun HJ, Cho KH, Lee EB - Journal of Korean medical science (2012). Not Altered. CC.

There are many types of Systemic lupus erythematous (SLE) which include:

  • Diffuse lupus nephritis
  • Membranous Lupus Nephritis
  • Advanced Sclerosing Lupus Nephritis
  • Chronic Discoid Lupus Erythematous
  • Subacute Cutaneous Lupus Erythematous
  • Drug-Induced Lupus Erythematosus

Diffuse lupus nephritis is class IV glomerulonephritis that involves more than 50% of all glomeruli with subendothelial deposits.

Membranous lupus nephritis is class V glomerulonephritis consists of global or segmental sub epithelial immune deposits that occur in combination with manifestations in class III or IV. It shows mesangial hyper cellularity and advanced sclerosis.

Advanced sclerosing lupus nephritis is class VI glomerulonephritis that  involves more than 90% or the glomeruli that shows global sclerosis.

Chronic discoid lupus erythematous is the most common type of cutaneous lupus erythematosus that is characterized by scaly, disk-like plaques on the scalp, face, and ears.

Subacute cutaneous lupus erythematous is a type of cutaneous lupus erythematosus that is characterized by widespread photosensitive rash that is non-scarring.

Drug-induced lupus erythematosus is a type of lupus that is triggered by certain medications and presents features that overlap with systemic lupus erythematosus. 

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Last updated on May 27, 2022