Types of hypersensitivity associated with insulin-related allergy reactions. Type I hypersensitivity reaction is characterized to be a TH2-controlled IgE-insulin specific mediated process, with local edema, itching, wheals, and flares, which could also be associated with angioedema. Type III hypersensitivity is mediated by antigen-antibody complex and recruitment of complement C1q, with subsequent edema, necrosis, and nodule formation. Finally, Type IV reactions are CD8-cytotoxic specific with subcutaneous edema, itching, and hyperkeratosis. Successful management of insulin allergy and autoimmune polyendocrine syndrome type 4 with desensitization therapy and glucocorticoid treatment: a case report and review of the literature. Rojas J, Villalobos M, Martínez MS, Chávez-Castillo M, Torres W, Mejías JC, Miquilena E, Bermúdez V - Case reports in immunology (2014). Not Altered. CC.